{"id":43680,"date":"2024-04-09T10:23:04","date_gmt":"2024-04-09T07:23:04","guid":{"rendered":"https:\/\/mu-sofia.bg\/international-activities\/bnrrp\/research-groups\/oncosurgery-and-genetics-of-head-and-neck-cancer\/"},"modified":"2024-04-09T10:23:32","modified_gmt":"2024-04-09T07:23:32","slug":"oncosurgery-and-genetics-of-head-and-neck-cancer","status":"publish","type":"page","link":"https:\/\/mu-sofia.bg\/en\/international-activities\/bnrrp\/research-groups\/oncosurgery-and-genetics-of-head-and-neck-cancer\/","title":{"rendered":"Oncosurgery and genetics of head and neck cancer"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"43680\" class=\"elementor elementor-43680 elementor-43170\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-360c85c elementor-section-stretched elementor-section-full_width elementor-section-height-min-height elementor-section-height-default elementor-section-items-middle\" data-id=\"360c85c\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-521990f\" data-id=\"521990f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-04cd7cc elementor-widget elementor-widget-heading\" data-id=\"04cd7cc\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">RESEARCH UNIVERSITY<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d4df6f0 elementor-nav-menu__align-center elementor-nav-menu--dropdown-mobile elementor-nav-menu__text-align-aside elementor-nav-menu--toggle elementor-nav-menu--burger elementor-widget elementor-widget-nav-menu\" data-id=\"d4df6f0\" data-element_type=\"widget\" data-settings=\"{&quot;layout&quot;:&quot;horizontal&quot;,&quot;submenu_icon&quot;:{&quot;value&quot;:&quot;&lt;i class=\\&quot;fas fa-caret-down\\&quot; aria-hidden=\\&quot;true\\&quot;&gt;&lt;\\\/i&gt;&quot;,&quot;library&quot;:&quot;fa-solid&quot;},&quot;toggle&quot;:&quot;burger&quot;}\" data-widget_type=\"nav-menu.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<nav aria-label=\"Menu\" class=\"elementor-nav-menu--main elementor-nav-menu__container elementor-nav-menu--layout-horizontal e--pointer-underline e--animation-fade\">\n\t\t\t\t<ul id=\"menu-1-d4df6f0\" class=\"elementor-nav-menu\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-42640\"><a href=\"https:\/\/mu-sofia.bg\/mezhdunarodna-dejnost\/npvu\/za-proekta\/\" class=\"elementor-item\">About<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-42821\"><a href=\"https:\/\/mu-sofia.bg\/mezhdunarodna-dejnost\/npvu\/nauchni-grupi\/\" class=\"elementor-item\">Research groups<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-42830\"><a href=\"https:\/\/mu-sofia.bg\/mezhdunarodna-dejnost\/npvu\/kontakti\/\" class=\"elementor-item\">Contacts<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t<div class=\"elementor-menu-toggle\" role=\"button\" tabindex=\"0\" aria-label=\"Menu Toggle\" aria-expanded=\"false\">\n\t\t\t<i aria-hidden=\"true\" role=\"presentation\" class=\"elementor-menu-toggle__icon--open eicon-menu-bar\"><\/i><i aria-hidden=\"true\" role=\"presentation\" class=\"elementor-menu-toggle__icon--close eicon-close\"><\/i>\t\t<\/div>\n\t\t\t\t\t<nav class=\"elementor-nav-menu--dropdown elementor-nav-menu__container\" aria-hidden=\"true\">\n\t\t\t\t<ul id=\"menu-2-d4df6f0\" class=\"elementor-nav-menu\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-42640\"><a href=\"https:\/\/mu-sofia.bg\/mezhdunarodna-dejnost\/npvu\/za-proekta\/\" class=\"elementor-item\" tabindex=\"-1\">About<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-42821\"><a href=\"https:\/\/mu-sofia.bg\/mezhdunarodna-dejnost\/npvu\/nauchni-grupi\/\" class=\"elementor-item\" tabindex=\"-1\">Research groups<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-42830\"><a href=\"https:\/\/mu-sofia.bg\/mezhdunarodna-dejnost\/npvu\/kontakti\/\" class=\"elementor-item\" tabindex=\"-1\">Contacts<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-acb1a09 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"acb1a09\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1eaa3b0\" data-id=\"1eaa3b0\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-92b70a4 elementor-widget elementor-widget-heading\" data-id=\"92b70a4\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">research group<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0ccb8b0 elementor-widget elementor-widget-heading\" data-id=\"0ccb8b0\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Oncosurgery and genetics of head and neck cancer<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e5e0fa2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e5e0fa2\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-extended\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-ce0b85a\" data-id=\"ce0b85a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3b5ab02 elementor-widget elementor-widget-heading\" data-id=\"3b5ab02\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Main research area of the group<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8eff2ef elementor-widget elementor-widget-text-editor\" data-id=\"8eff2ef\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tHead and neck cancer and field cancerization &#8211; from comprehensive RNA-seq profiling to possible clinical translation\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7823d39 elementor-widget elementor-widget-heading\" data-id=\"7823d39\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Leading researcher:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-70494d0 elementor-widget elementor-widget-text-editor\" data-id=\"70494d0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Assoc. Prof. Todor Miroslavov Popov, MD, PhD<\/strong><\/p>\n<p>Department of ENT, Faculty of Medicine, MU \u2013 Sofia<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-3ebdc06\" data-id=\"3ebdc06\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0c89868 elementor-widget elementor-widget-heading\" data-id=\"0c89868\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Members of the research team:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-88d0657 elementor-widget elementor-widget-text-editor\" data-id=\"88d0657\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul>\n<li>Gergana Stancheva, PhD;<\/li>\n<li>Silva Kyurkchiyan, PhD;<\/li>\n<li>Zahari Vinarov, PhD (pro bono)<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ad6aa26 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ad6aa26\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-extended\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-24cf549\" data-id=\"24cf549\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-43a14f9 elementor-widget elementor-widget-heading\" data-id=\"43a14f9\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Research goals<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-43d3fa4 elementor-widget elementor-widget-text-editor\" data-id=\"43d3fa4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Current medical protocols for head and neck squamous cell carcinoma are deficient in viable biomarkers for more personalized therapeutic approaches. This study aims to uncover such potential biomarkers regarding the prediction of recurrence and delineating field cancerization in this type of cancer. Total RNA and microRNA next generation sequencing would grant us a comprehensive set of data that could guide the selection of such candidates for qRT-PCR validation and in situ hybridization topographic visualization.<\/p>\n<p>Objectives:<br \/>\n1. Enlarging our biobank with samples from squamous cell carcinoma up to 120<br \/>\npatients with cancer of the oral cavity, oropharynx, hypopharynx and larynx. Sample collection would include tumor tissue, histologically normal peritumor mucosa, distant control mucosa and plasma.<br \/>\n2. Conduct total RNA and microRNA next-generation sequencing in a designated group of 10-12 patients from each subsite of cancer origin.<br \/>\n3. Conduct HPV infection analysis of the samples.<br \/>\n4. Conduct integrated analysis of the RNA profiles obtained from the next-generation sequencing and based on that, select candidate molecules with abnormal expression levels for possible biomarker potential and further investigation.<\/p>\n<p>5. Conduct qRT-PCR validation of the selected RNA molecules across the whole\u00a0cohort.<br \/>\n6. Analyze possible associations of these molecules with clinical characteristics and survival outcomes.<br \/>\n7. Detect RNA molecules with abnormal expression levels in histologically normal peritumor mucosa that have the same pattern of expression in tumor tissue, i.e., find potential biomarkers for field of cancerization.<br \/>\n8. Visualize some of the selected potential biomarkers with in situ hybridization.<br \/>\n9. Attempt to refine in situ hybridization techniques and methodology for accelerating the process of visualization with the help of phospholipid nanoparticles thus getting closer to a possible perioperative utilization of these findings and achieving translational application.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-69e498d\" data-id=\"69e498d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>RESEARCH UNIVERSITY research group Oncosurgery and genetics of head and neck cancer Main research area of the group Head and neck cancer and field cancerization &#8211; from comprehensive RNA-seq profiling to possible clinical translation Leading researcher: Assoc. Prof. Todor Miroslavov Popov, MD, PhD Department of ENT, Faculty of Medicine, MU \u2013 Sofia Members of the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":43641,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-43680","page","type-page","status-publish","hentry","wpbf-post"],"_links":{"self":[{"href":"https:\/\/mu-sofia.bg\/en\/wp-json\/wp\/v2\/pages\/43680","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mu-sofia.bg\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/mu-sofia.bg\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/mu-sofia.bg\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mu-sofia.bg\/en\/wp-json\/wp\/v2\/comments?post=43680"}],"version-history":[{"count":0,"href":"https:\/\/mu-sofia.bg\/en\/wp-json\/wp\/v2\/pages\/43680\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/mu-sofia.bg\/en\/wp-json\/wp\/v2\/pages\/43641"}],"wp:attachment":[{"href":"https:\/\/mu-sofia.bg\/en\/wp-json\/wp\/v2\/media?parent=43680"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}