{"id":43744,"date":"2024-04-09T11:06:23","date_gmt":"2024-04-09T08:06:23","guid":{"rendered":"https:\/\/mu-sofia.bg\/international-activities\/bnrrp\/research-groups\/oncogenetics-and-genomics\/"},"modified":"2024-04-09T11:06:56","modified_gmt":"2024-04-09T08:06:56","slug":"oncogenetics-and-genomics","status":"publish","type":"page","link":"https:\/\/mu-sofia.bg\/en\/international-activities\/bnrrp\/research-groups\/oncogenetics-and-genomics\/","title":{"rendered":"Oncogenetics and genomics"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"43744\" class=\"elementor elementor-43744 elementor-43263\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-eb95132 elementor-section-stretched elementor-section-full_width elementor-section-height-min-height elementor-section-height-default elementor-section-items-middle\" data-id=\"eb95132\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3add02e\" data-id=\"3add02e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-72d17d4 elementor-widget elementor-widget-heading\" data-id=\"72d17d4\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">RESEARCH UNIVERSITY<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7063407 elementor-nav-menu__align-center elementor-nav-menu--dropdown-mobile 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class=\"elementor-item\">About<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-42821\"><a href=\"https:\/\/mu-sofia.bg\/mezhdunarodna-dejnost\/npvu\/nauchni-grupi\/\" class=\"elementor-item\">Research groups<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-42830\"><a href=\"https:\/\/mu-sofia.bg\/mezhdunarodna-dejnost\/npvu\/kontakti\/\" class=\"elementor-item\">Contacts<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t<div class=\"elementor-menu-toggle\" role=\"button\" tabindex=\"0\" aria-label=\"Menu Toggle\" aria-expanded=\"false\">\n\t\t\t<i aria-hidden=\"true\" role=\"presentation\" class=\"elementor-menu-toggle__icon--open eicon-menu-bar\"><\/i><i aria-hidden=\"true\" role=\"presentation\" class=\"elementor-menu-toggle__icon--close eicon-close\"><\/i>\t\t<\/div>\n\t\t\t\t\t<nav class=\"elementor-nav-menu--dropdown elementor-nav-menu__container\" aria-hidden=\"true\">\n\t\t\t\t<ul id=\"menu-2-7063407\" class=\"elementor-nav-menu\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-42640\"><a href=\"https:\/\/mu-sofia.bg\/mezhdunarodna-dejnost\/npvu\/za-proekta\/\" class=\"elementor-item\" tabindex=\"-1\">About<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-42821\"><a href=\"https:\/\/mu-sofia.bg\/mezhdunarodna-dejnost\/npvu\/nauchni-grupi\/\" class=\"elementor-item\" tabindex=\"-1\">Research groups<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-42830\"><a href=\"https:\/\/mu-sofia.bg\/mezhdunarodna-dejnost\/npvu\/kontakti\/\" class=\"elementor-item\" tabindex=\"-1\">Contacts<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e571a20 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e571a20\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-eb04a13\" data-id=\"eb04a13\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3f94f66 elementor-widget elementor-widget-heading\" data-id=\"3f94f66\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">research group<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-473b392 elementor-widget elementor-widget-heading\" data-id=\"473b392\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Oncogenetics and genomics<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b9ac03e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b9ac03e\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-extended\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-c239e2e\" data-id=\"c239e2e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-74e7381 elementor-widget elementor-widget-heading\" data-id=\"74e7381\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Main research area of the group<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7ad3bb9 elementor-widget elementor-widget-text-editor\" data-id=\"7ad3bb9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<span id=\"E515\">Cancer biology, molecular pathology and diagnostics, cancer genetics and genomics, precision medicine<\/span><span id=\"E516\"> <\/span>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cf44cd8 elementor-widget elementor-widget-heading\" data-id=\"cf44cd8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Leading researchers<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c4b0fee elementor-widget elementor-widget-text-editor\" data-id=\"c4b0fee\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Prof. Radka Petrova Kaneva, PhD<\/strong><\/p>\n<p>Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical Faculty, MU \u2013 Sofia<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-431a989\" data-id=\"431a989\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-001fa70 elementor-widget elementor-widget-heading\" data-id=\"001fa70\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Members of the research team:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fb8f417 elementor-widget elementor-widget-text-editor\" data-id=\"fb8f417\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Associate Professor, PhD, Anelia Horvath; Acad. MD, PhD, DSci, Prof. Chavdar Slavov; Prof, MD, Marincho Georgiev; Prof, MD, Nikolay Gabrovsky; Associate Professor, MD, Rumen Dimitrov; Associate Professor, MD, Atanas Yonkov; Associate Professor, MD, Theophil Sedloev; MD, PhD, Kalin Vidinov; Associate Professor, MD, PhD, Vesela Ivanova; Chief Assistant Prof., PhD, Olga Beltcheva; Assistant, PhD, Darina Kachakova-Yordanova; PhD, Rumyana Dodova; Assistant Prof., PhD, Daniela Pencheva; PhD, Kunka Kamenarova; MD, PhD, Slavyana Usheva; Assoc Prof. Elenko Popov, MD, PhD; Reni Tzveova, PhD<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9020f06 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9020f06\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-extended\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-a041ad8\" data-id=\"a041ad8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cb76fbf elementor-widget elementor-widget-heading\" data-id=\"cb76fbf\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Research goals<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-35e188b elementor-widget elementor-widget-text-editor\" data-id=\"35e188b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>One of the goals of the research group is to continue our work on familial cancers using the modern large-scale NGS technologies. By performing whole exome sequencing in patients with familial cancers, that tested negative for mutations in BRCA1\/2 and MMR-related genes, we plan to identify pathogenic mutations and set of genes contributing to the most common familial type of cancers, such as hereditary breast and ovarian, prostate, colorectal and other rare familial types of cancer in the Bulgarian population.<br \/>\nCancer, as other complex traits, is polygenic. Genome-wide association studies (GWASs) have identified hundreds of independent cancer susceptibility loci containing common, low-risk variants. Estimation of heritability due to additive effects of all single-nucleotide polymorphisms (SNPs) included in GWAS arrays shows that common variants have substantial potential to identify individuals at different levels of risk for many cancer types. The accumulation of whole exome and genome data from Bulgarian cancer patients, coupled with genome data from healthy people in the frame of other research initiatives such as Genome of Europe, 1+M genomes, and PRACTICAL consortium, will allow us to investigate the use of polygenic risk scores to guide cancer screening and prevention strategies with the aim of implementing them on a national scale in the future.<br \/>\nThe ongoing collaboration of Molecualr Medicine Center with leading university clinics of surgery and the establishment in our biobank of collections of different types of fresh frozen tumors will give us the possibility to upply a multi-omics approach to study the specific molecular characteristics of various solid tiumours. We aim to apply whole exome sequencing in search of somatic mutations and to couple it with whole transcriptome and methylation profiling into a combined system biology analysis. This approach will be applied on different solid tumours to provide better molecular subclasification and diagnostics, but also to identify tumour specific markers and potential therapeutic targets.<br \/>\nThe molecular heterogeneity of cancer is one of the major causes of drug resistance that leads to treatment failure. To understand better the heterogeneity of cancer and the role of microenvironment we aim to apply spatial transcriptomics. Recently single-cell sequencing has become an important tool for investigating tumor heterogeneity, however, it misses the spatial information of the analyzed cells. By using spatial transcriptomics and providing localization-indexed gene expression information we aim to study the nature of both inter-tumour and intra-tumor heterogeneity, tumor immune microenvironment, and matrix microenvironment, as well as the pathological classification and prognosis of cancer.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-69fceb2\" data-id=\"69fceb2\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>RESEARCH UNIVERSITY research group Oncogenetics and genomics Main research area of the group Cancer biology, molecular pathology and diagnostics, cancer genetics and genomics, precision medicine Leading researchers Prof. Radka Petrova Kaneva, PhD Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical Faculty, MU \u2013 Sofia Members of the research team: Associate Professor, PhD, Anelia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":43641,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-43744","page","type-page","status-publish","hentry","wpbf-post"],"_links":{"self":[{"href":"https:\/\/mu-sofia.bg\/en\/wp-json\/wp\/v2\/pages\/43744","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mu-sofia.bg\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/mu-sofia.bg\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/mu-sofia.bg\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mu-sofia.bg\/en\/wp-json\/wp\/v2\/comments?post=43744"}],"version-history":[{"count":0,"href":"https:\/\/mu-sofia.bg\/en\/wp-json\/wp\/v2\/pages\/43744\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/mu-sofia.bg\/en\/wp-json\/wp\/v2\/pages\/43641"}],"wp:attachment":[{"href":"https:\/\/mu-sofia.bg\/en\/wp-json\/wp\/v2\/media?parent=43744"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}