IMOGEN will aim at 1) the development of a robust imaging approach for 3D-imaging of the macro- and microvasculature with the highest possible resolution; 2) transcriptome profiling in normal and pathological angiogenesis and comparing the expression perturbations observed in tissue and blood cells genomes; 3) expression profiling of stem cells with angiogenic potential and animal model analysis; 4) validation and meta-analysis of the most prominent markers and identification of potential targets for new therapeutic interventions; 5) the development of state–of–the–art transcriptomics/proteomics facility for angiogenesis research in Medical University Sofia offering high-quality research services to users from different countries.