The research goal of the program is to identify NPs as potential therapeutic modalities in models of NCDs. The phytochemical group will obtain extracts of different polarity with subsequent metabolite profiling of selected plant taxa. The extracts/BACs will undergo pharmacological testing in experimental models of NCDs namely neoplastic diseases (leukemias, lymphomas and solid tumors, including multidrug-resistant models), metabolic syndrome (with a tiered evaluation of effects on type 2 diabetes mellitus, essential hypertension and hyperuricemia), arthritis, inflammation and pain. The successful realization of the envisaged program will enable the formation of an interdisciplinary expert hub and research center for evidence-based pharmacology of natural products.